Physiological Responses to Intermittent Hypoxia in Humans | Jon C. Kolb | Health & Self Improvement | Medical | eBooks
Physiological Responses to Intermittent Hypoxia in Humans
by Jon C. Kolb
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Windows Vista / XP / 2000, Mac OS X Tiger Features
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Physiological Responses to Intermittent Hypoxia in Humans Summary:
| Recently, endurance athletes and high altitude climbers have gained access to commercially available, portable normobaric hypoxic chambers. Intermittent exposures to hypoxia in these chambers may elicit adaptations similar to those observed during acclimatization to altitude. Manufactures of these systems purport that intermittent exposures may elicit adaptations similar to those observed in response to the hypoxia of high altitude, however there have been no reports in the scientific literature that ventilatory acclimatization or alterations in cerebrovascular dynamics occur following repeated episodes in the portable chambers. The goal of this dissertation is to provide a detailed investigation into the physiologic and symptomatic responses following an intervention of discontinuous normobaric hypoxia, which employs portable chambers. To accomplish this, an intermittent protocol was developed which cycled between 8 hrs of nocturnal hypoxia at a simulated altitude of 4300m, followed by 16 hrs of normoxia, for five consecutive days. Specifically, it is not currently known if cerebrovascular and ventilatory sensitivities to acute hypoxia are altered, or if altitude-like symptoms develop, in response to such an intermittent hypoxic protocol. The studies within the thesis are separated into four distinct phases, which were conducted sequentially. This sequential construction of the thesis was necessary because the results of each phase helped to finalize the research protocol for each subsequent investigation. The following summary outlines the progression and key findings related to the series of experiments. A critical comparison between the non-invasive measurements of oxygen saturation with direct blood measurements revealed that pulse oximetry is a reliable method to monitor levels of hypoxemia during mild to moderate exposures of normobaric hypoxia. Subsequently, in order to establish a method for the quantification of cerebrovascular and ventilatory response... |
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