This book provides a critical evaluation of proposed experimental animal models and approaches and discusses the contribution immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. It addresses emerging methodologies at the cellular and molecular levels, advances in and requirements for animal model development in testing for allergenicity of foods and genetically modified products, and animal models of autoimmunity associated with chemical exposure. The presentation also includes recommendations for the selection of sentinel species in ecotoxicology and an in-depth review of immunotoxicology as it relates to a variety of wildlife species.