Twice before, the ruthless religious fanatic known as Jeremiah has sought to impose his own twisted brand of theocracy on the world. Now, with the preparations for a new global apocalypse in place, Jeremiah must choose which, if either, of his two sons will be his chosen successor. He pits his heirs against each other, testing their worthiness, while gradually revealing his diabolical scheme to unleash a deadly plague on the world, using a unique and ingenious delivery system.

Heeding his latest "revelation" from God, the madman intends to achieve true immortality -- by means of transplanted organs from his innocent clone.