In 1908, she married the British essayist and journalist, Basil de S?lincourt. During World War I she and her husband were volunteer workers in hospitals and orphanages in France.

Her novels explored the contrast in values between Americans and Europeans. He bestsellin novel Tante was made into a 1918 film, The Impossible Woman and The Little French Girl into a 1925 film of the same name. In 1931, she was elected to the United States National Institute of Arts and Letters. Four of her books were on the list of bestselling novels in the United States for 1912, 1924, 1927, and 1929 as determined by the New York Times.

Anne Douglas Sedgwick died in Hampstead, England in 1935. The following year her husband published "Anne Douglas Sedgwick: A Portrait in Letters."