This volume is a scholarly reference to published research results on the neurobiology and neuroanatomy of depression and the association of depression with disorders of the central nervous system. The book reviews and discusses aspects of recent research on the underlying mechanisms of depression, including neurotransmitter dysregulation, hypothalamus-pituitary-adrenal axis abnormalities, and cellular resistance. Illustrated with tables, graphs, and charts, Depression and Brain Dysfunction is the first book to include the recent advances in functional neuroimaging of the structural and anatomical defects in patients with significant symptoms of depression.