Free spirit Alys Seagraves and her elderly, eccentric friend Mame are about to embark upon an epic road trip along historic Route 66 when Mame suffers a medical setback that throws a wrench into their plans. Never the willing patient, Mame sneaks out of the hospital, determined to go it alone as she relives the memories of her honeymoon along the famous highway. Now Alys has to trail the spunky senior westward and bring her back to reality.

Yet Alys isn’t alone. Mame’s nephew Elliot Ross, a very sexy but very serious doctor, is sharing the driving duties. Elliot has a voice like velvet and eyes to match. The impromptu couple will be spending many hours together in an aging pink Cadillac—and the sparks are destined to fly. After retracing the romantic path that Mame and her late husband followed long ago, Alys and Elliot will discover on the sunny shores of California that one must always live for the moment…and take a chance on love.