In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available. Amyloid Precursor Protein: A Practical Approach presents a variety of biological techniques utilized in genetics, molecular biology, cell biology, and biochemistry to elucidate the structure and function of this transmembrane protein. Each technique is presented with detailed, step-by-step protocols to achieve reproducible results and provide a framework for studying other membrane proteins. These protocols also form the core of the authors' approach to elucidating the function of APP.